Bioactive Small Molecules
Cayman Chemical ANTIBODY OSI-930 25mg
A dual inhibitor of Kit (IC50s = 80 and 629 nM for the actived and non-activated kinase, respectively, in cell-free assays) and the kinase insert domain receptor (KDR; IC50 = 9 nM); selective for these kinases over a panel of 13 additional kinases (IC50s = 1.3->10 µM) but also inhibits FLT1, CSF1R, C-RAF, and LCK (IC50s = 8, 15, 41, and 22 nM, respectively); inhibits Kit autophosphorylation in NCI-H526 and HMC-1 cells expressing wild-type Kit and Kit containing the constitutively active KitV560G mutation, respectively, and stem cell factor-induced Kit autophosphorylation in NCI-H526 cells expressing wild-type Kit (IC50s = 58.1 and 78.9 nM, respectively); inhibits VEGF-induced autophosphorylation of VEGFR2 in HUVECs (IC50 = 64.4 nM); decreases endothelial sprout formation by >50% in isolated rat aortic rings at 100 nM; reduces tumor growth in a variety of mouse xenograft models at 200 mg/kg per day
Medchemexpress LLC (±)-α-Tocopherol nicotinate | 51898-34-1 | 99.8% | 5 G
(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. It is hydrolyzed in the blood to α-tocopherol and niacin and may be used in studies of related vascular diseases.
- Prevents lipid peroxidation in cell membranes.
- Hydrolyzed in the blood to α-tocopherol and niacin.
- May be used in studies of related vascular diseases.
- Can help slow the progression of microangiopathy in type 2 diabetics by reducing lipid peroxidation stress in the red blood cell membrane, improving blood rheology and red blood cell deformability.
- Increases the proportion of CD4+CD8-T cells in thymocytes.
Cayman Chemical alcIs4 7 10 13 16Docosape 5mg
A derivative of DPA often used in formulations designed as dietary supplements
Cayman Chemical ANTIBODY RItnserIn 25mg
A potent 5-HT2A receptor antagonist; selective for 5-HT2A over 5-HT1 receptors (IC50s = 0.9 nM and >1000 nM, respectively); has 39-, 77-, 107-, and 166-fold lower affinity for H1, D2, α1-adrenergic, and α2-adrenergic receptors, respectively; blocks 5-hydroxy tryptophan-induced head twitches in rats at a dose of 10 mg/kg
Medchemexpress LLC CXCR2 antagonist 8 | 182498-30-2 | 98.38% | 303.27 | 50 MG
CXCR2 antagonist 8 is a potent and selective CXCR2 antagonist that can be utilized for insulin resistance research. It is intended for research use only and is not sold to patients. This product has a solid appearance with a color ranging from light yellow to brown.
- Potent and selective CXCR2 antagonist
- Utilized for insulin resistance research
- Solid appearance, light yellow to brown color
Cayman Chemical ANTIBODY PF-3450074 5mg
An inhibitor of HIV-1 capsid protein; reduces viral infectivity in HeLa cells infected with wild-type HIV-1 but not P38A, E45A, Q63A/Q67A, or Q219A capsid protein mutant HIV-1, simian immunodeficiency virus, or murine leukemia virus at 10 µM; reduces capsid protein levels in HIV-1 viral cores
Cayman Chemical ANTIBODY CAY10771 5mg
A dual agonist of FXR and PPARδ; activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 µM, respectively); selective for these receptors over RARα, RXRα, PPARα, PPARγ, and LXRα at 10 µM
Cayman Chemical ANTIBODY FluzoparIb 5mg
A PARP1 inhibitor (IC50 = 1.46 nM); induces DNA double-strand breaks in wild-type, but not BRCA2-/-, V-C8 cells, as well as BRCA1-/- MDA-MB-436 cells at 1 and 10 µM; inhibits the proliferation of BRCA2-/- V-C8 cells (IC50 = 0.053 µM), BRCA1-/- MDA-MB-436, UWB1.289, and MX-1 cells (IC50s = 0.51, 1.57, and 1.57 µM, respectively), and OVCAR-8 cells containing hypermethylated BRCA1 (IC50 = 1.43 µM); reduces tumor formation in an MDA-MB-436 mouse xenograft model at 1 and 3 mg/kg
Medchemexpress LLC Carglumic Acid | 1188-38-1 | MFCD00047874 | 1 ML
Carglumic acid (N-Carbamyl-L-glutamic acid) is a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator. It is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.
- Functional analogue of N-acetylglutamate (NAG).
- Activates carbamoyl phosphate synthetase 1 (CPS1).
- Used to treat acute and chronic hyperammonemia.
- Suppresses cell viability in pancreatic, breast, hepatoma, and lung cancer cell lines.
- Significantly inhibits tumor growth in orthotopic cancer models.
Cayman Chemical ANTIBODY BTZ043 10mg
An antibiotic with antimycobacterial activity; targets mycobacterial cell wall synthesis by inhibiting DprE1; active against various Mycobacterium species in vitro, including M. smegmatis, M. bovis, and M. tuberculosis (MICs = 4, 2, and 1 ng/ml, respectively), as well as the actinobacterium N. brasiliensis (MIC50 = 0.125 μg/ml); active against M. tuberculosis in RAW 264.7 murine macrophages (MIC = M. tuberculosis cells in lung and spleen in a mouse model of chronic tuberculosis infection at 37.5 or 300 mg/kg for four weeks
Cayman Chemical ANTIBODY QuInInIb 500ug
A CysLT1 and CysLT2 receptor antagonist (IC50s = 1.4 and 52 µM, respectively); inhibits tubule formation in HMEC-1 cells at 3.16 and 10 µM; inhibits sprout formation in isolated mouse aortic rings at 10 µM; decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization at 0.5 and 3 µM, as well as increasing neovascularization and vascular density at 3 µM; reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model at 50 mg/kg every three days
Cayman Chemical ANTIBODYR S-CHPG 25mg
A potent and selective agonist at mGluR5; EC50 of 750 µM for calcium mobilization in CHO mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells; in transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors
Cayman Chemical ANTIBODY MLE-4901 50mg
An NK3 receptor antagonist; inhibits human liver microsomal CYP3A4/5 (apparent IC50s = 7.1 and 19.8 μM in midazolam 1'-hydroxylation and testosterone 6β-hydroxylation assays, respectively)